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Prednisone or another corticosteroid can prevent blindness when it is used to calm acute inflammation of blood vessels in the head, called giant cell arteritis. But if the inflammation occurs in areas that do not have an established history of blood vessels, such as the nose or mouth, then the treatment can also induce permanent blindness.In one of the study methods, investigators implanted a small biopsy of eyeball stem cells in a small mouse, which they later cultured to see why their new eyeball cells reacted in such a way. The study suggests that stem cells may be a better therapeutic target for large scale treatment of GCA (as opposed to smaller studies in which cells are taken directly from the patient's eyeball).The findings suggest that stem cells may be more effective in treating a group of different conditions that are associated with retinal diseases, including the following:In the past, scientists thought that stem cells were best suited to treat degenerative retinal diseases (such as cataracts in the eye or diabetic retinopathy in the eye), but the authors argue that current thinking may not be correct. In fact, they say that it may be more likely that they can be used more effectively for a variety of different conditions such as GCA. The new method is an extension of a prior research on regenerating retina-like tissue (like that taken from a pig) to develop different treatments. The research team also suggests that the stem cells may be more effective for conditions in which the body already has some of its own stem cells: if they can be used in an eyeball to develop an eyeball-like tissue in the patient's body, then the eyeball may eventually be removed by a doctor as well.The new study was not conducted in a "blind" setting, in which the patient is unaware of what has been given to him/her. But this isn't likely because scientists need to make sure that the cells work correctly in a patient's eyes before they are given to a patient. This method is designed without being told if the patient will get a benefit even if they are not aware that they are receiving any drug treatment. So while it will be difficult to tell exactly what is being given and when, it remains a possibility that the researchers may eventually have the ability to identify the source of some of their cells. The research is still in the early stages and the results will have to be confirmed as the study continues.The National Human Genome Research Institute, part of the National Institutes of Health, funded the research.The study was published in the Journal of Investigative Ophthalmology and Visual Science.MoreRelated Article: